3D07

Human p53 core domain with hot spot mutation R249S (III)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cellular tumor antigen p53	polymer	200	22435.5	2	UniProt (P04637) Pfam (PF00870)	Homo sapiens (Human)	Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13
2	C, D (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	E, F (A, B)	water	water		18.0	305	Chemie (HOH)

Sequence modifications

A, B: 94 - 293 (UniProt: P04637)

PDB	External Database	Details
Ser 249	Arg 249	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	44870.9
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	45001.8

*Water molecules are not included.