3CWE
PTP1B in complex with a phosphonic acid inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 290 | 33709.6 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | B, C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | E (A) | [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid | non-polymer | 495.3 | 1 | Chemie (825) | |||
| 4 | F (A) | water | water | 18.0 | 318 | Chemie (HOH) |
Sequence modifications
A: 501 - 783 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Ala 494 | - | expression tag |
| Ala 495 | - | expression tag |
| Asp 496 | - | expression tag |
| Lys 497 | - | expression tag |
| Leu 498 | - | expression tag |
| Glu 499 | - | expression tag |
| Phe 500 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33709.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 568.2 | |
| All* | Total formula weight | 34277.8 |
