3CTQ
Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 348 | 39800.6 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (man) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | B (A) | N-benzyl-1-[5-({5-tert-butyl-2-methoxy-3-[(methylsulfonyl)amino]phenyl}carbamoyl)-2-methylphenyl]-1H-1,2,3-triazole-4-carboxamide | non-polymer | 590.7 | 1 | Chemie (337) | |||
| 3 | C (A) | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 5 - 352 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Ala 14 | Asn 14 | conflict |
| His 48 | Leu 48 | conflict |
| Ala 120 | Gln 120 | conflict |
| Ala 263 | Thr 263 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39800.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 590.7 | |
| All* | Total formula weight | 40391.3 |
