3CSF
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 966 | 110727.1 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (Human) | PI3-kinase p110 subunit gamma, PtdIns-3- kinase subunit p110, PI3K, PI3Kgamma, p110-PI3K |
| 2 | B (A) | RU-PYRIDOCARBAZOLE-2 | non-polymer | 496.4 | 1 | Chemie (DW2) | |||
| 3 | C (A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
| PDB | External Database | Details |
|---|---|---|
| Met 143 | - | expression tag |
| His 1103 | - | expression tag |
| His 1104 | - | expression tag |
| His 1105 | - | expression tag |
| His 1106 | - | expression tag |
| His 1107 | - | expression tag |
| His 1108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 110727.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 496.4 | |
| All* | Total formula weight | 111223.5 |
