3CQA
Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heparin-binding growth factor 1 | polymer | 144 | 16294.3 | 2 | UniProt (P05230) Pfam (PF00167) | Homo sapiens (Human) | HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF- beta |
| 2 | C, E (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D, F (A, B) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 140 (UniProt: P05230)
| PDB | External Database | Details |
|---|---|---|
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| His 1 | - | expression tag |
| His 1 | - | expression tag |
| Ala 81 | Glu 96 | engineered mutation |
| Ala 101 | Lys 116 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32588.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 284.2 | |
| All* | Total formula weight | 32872.8 |
