3CQA

Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heparin-binding growth factor 1	polymer	144	16294.3	2	UniProt (P05230) Pfam (PF00167) In PDB	Homo sapiens (Human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF- beta
2	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	A, B	FORMIC ACID	non-polymer		46.0	2	Chemie (FMT)
4		water	water		18.0	220	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 0	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Ala 81	Glu 96	engineered mutation
Ala 101	Lys 116	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32588.6
Non-Polymers*	Number of molecules	4
	Total formula weight	284.2
All*	Total formula weight	32872.8

*Water molecules are not included.