3CPB
Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Vascular endothelial growth factor receptor 2 | polymer | 314 | 36284.6 | 2 | UniProt (P35968) Pfam (PF07714) In PDB | Homo sapiens (Human) | VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen |
2 | A, B | N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide | non-polymer | 366.5 | 2 | Chemie (C92) | |||
3 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A, B: 815 - 939 (UniProt: P35968)
A, B: 990 - 1171 (UniProt: P35968)
PDB | External Database | Details |
---|---|---|
Ala 817 | Cys 817 | engineered mutation |
Thr 916 | Val 916 | engineered mutation |
Arg 1172 | - | expression tag |
His 1173 | - | expression tag |
His 1174 | - | expression tag |
His 1175 | - | expression tag |
His 1176 | - | expression tag |
His 1177 | - | expression tag |
His 1178 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Val 990 | Glu 990 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72569.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 732.9 | |
All* | Total formula weight | 73302.1 |