3COT
Crystal structure of human liver delta(4)-3-ketosteroid 5beta-reductase (akr1d1) in complex with progesterone and nadp. Resolution: 2.03 A.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3-oxo-5-beta-steroid 4-dehydrogenase | polymer | 346 | 39599.3 | 2 | UniProt (P51857) Pfam (PF00248) | Homo sapiens (human) | Delta(4)-3-ketosteroid 5-beta-reductase, Aldo-keto reductase family 1 member D1 |
| 2 | C, E (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 3 | D, F (A, B) | PROGESTERONE | non-polymer | 314.5 | 2 | Chemie (STR) PubChem (16219863) PubChem (16401562) PubChem (16757724) PubChem (18635648) PubChem (4920) PubChem (5994) PubChem (92940) PubChem (23615931) PubChem (71200542) PubChem (44135692) PubChem (44275133) PubChem (44279092) PubChem (638017) PubChem (657254) PubChem (1807216) PubChem (1807215) PubChem (1807214) PubChem (54269928) PubChem (1274466) PubChem (57526392) PubChem (58483135) PubChem (58766357) PubChem (58872617) PubChem (5320716) PubChem (70865784) PubChem (70987742) PubChem (70987859) PubChem (6576615) PubChem (7048588) PubChem (7059604) PubChem (7059605) PubChem (7059606) PubChem (7092664) PubChem (7092665) PubChem (7092666) PubChem (9948776) PubChem (1201516) PubChem (11869413) PubChem (11869414) PubChem (11869415) PubChem (11876098) PubChem (11876099) PubChem (11876100) PubChem (12303971) PubChem (12303981) PubChem (12303986) PubChem (12303989) PubChem (12303992) PubChem (6603959) PubChem (7004693) PubChem (117072378) PubChem (118670641) PubChem (11869416) PubChem (144033743) PubChem (123410055) PubChem (12303982) PubChem (12303979) PubChem (129010392) PubChem (134688829) PubChem (135189961) PubChem (135190011) PubChem (135249041) PubChem (142168519) PubChem (142402781) PubChem (145130068) PubChem (170068371) PubChem (163070289) PubChem (163070290) PubChem (163070291) PubChem (163070292) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 497 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 326 (UniProt: P51857)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79198.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2115.7 | |
| All* | Total formula weight | 81314.3 |
