3CL3

Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ORF K13	polymer	183	20670.1	2	UniProt (P88961) Pfam (PF01335) UniProt (by SIFTS) (Q76RF1) In PDB	Human gammaherpesvirus 8	ks-vFLIP
2	D, E	NF-kappa-B essential modulator	polymer	130	14753.3	2	UniProt (Q9Y6K9) In PDB	Homo sapiens (human)	NEMO, NF-kappa-B essential modifier, Inhibitor of nuclear factor kappa-B kinase subunit gamma, IkB kinase subunit gamma, I-kappa-B kinase gamma, IKK-gamma, IKKG, IkB kinase-associated protein 1, IKKAP1, FIP-3

Sequence modifications

A, B: 1 - 178 (UniProt: P88961)

PDB	External Database	Details
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

D, E: 150 - 252 (UniProt: Q9Y6K9)

PDB	External Database	Details
Gly 143	-	expression tag
His 144	-	expression tag
Met 145	-	expression tag
Ala 146	-	expression tag
Ser 147	-	expression tag
Gly 148	-	expression tag
Ser 149	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	70846.9
All*	Total formula weight	70846.9

*Water molecules are not included.