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3CAQ

Crystal structure of 5beta-reductase (AKR1D1) in complex with NADPH

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
3-oxo-5-beta-steroid 4-dehydrogenasepolymer32637427.92UniProt (P51857)
Pfam (PF00248)
Homo sapiens (human)Delta(4)-3-ketosteroid 5-beta-reductase, Aldo-keto reductase family 1 member D1
2C, H
(A, B)
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.42Chemie (NDP)
3D, I
(A, B)
BETA-MERCAPTOETHANOLnon-polymer78.12Chemie (BME)
4E, F, J
(A, B)
1,2-ETHANEDIOLnon-polymer62.13Chemie (EDO)
5G, K
(A, B)
(4S)-2-METHYL-2,4-PENTANEDIOLnon-polymer118.22Chemie (MPD)
6L, M
(A, B)
waterwater18.0278Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight74855.8
Non-Polymers*Number of molecules9
Total formula weight2069.7
All*Total formula weight76925.5
*Water molecules are not included.

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PDB entries from 2025-07-30

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