3C7Q
Structure of VEGFR2 kinase domain in complex with BIBF1120
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vascular endothelial growth factor receptor 2 | polymer | 316 | 36557.0 | 1 | UniProt (P35968) Pfam (PF07714) | Homo sapiens (Human) | VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen |
| 2 | B, C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | G (A) | methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | non-polymer | 539.6 | 1 | Chemie (XIN) | |||
| 4 | H (A) | water | water | 18.0 | 206 | Chemie (HOH) |
Sequence modifications
A: 806 - 1171 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Gly 804 | - | expression tag |
| Ser 805 | - | expression tag |
| - | Thr 940 | deletion |
| - | Lys 941 | deletion |
| - | Gly 942 | deletion |
| - | Ala 943 | deletion |
| - | Arg 944 | deletion |
| - | Phe 945 | deletion |
| - | Arg 946 | deletion |
| - | Gln 947 | deletion |
| - | Gly 948 | deletion |
| - | Lys 949 | deletion |
| - | Asp 950 | deletion |
| - | Tyr 951 | deletion |
| - | Val 952 | deletion |
| - | Gly 953 | deletion |
| - | Ala 954 | deletion |
| - | Ile 955 | deletion |
| - | Pro 956 | deletion |
| - | Val 957 | deletion |
| - | Asp 958 | deletion |
| - | Leu 959 | deletion |
| - | Lys 960 | deletion |
| - | Arg 961 | deletion |
| - | Arg 962 | deletion |
| - | Leu 963 | deletion |
| - | Asp 964 | deletion |
| - | Ser 965 | deletion |
| - | Ile 966 | deletion |
| - | Thr 967 | deletion |
| - | Ser 968 | deletion |
| - | Ser 969 | deletion |
| - | Gln 970 | deletion |
| - | Ser 971 | deletion |
| - | Ser 972 | deletion |
| - | Ala 973 | deletion |
| - | Ser 974 | deletion |
| - | Ser 975 | deletion |
| - | Gly 976 | deletion |
| - | Phe 977 | deletion |
| - | Val 978 | deletion |
| - | Glu 979 | deletion |
| - | Glu 980 | deletion |
| - | Lys 981 | deletion |
| - | Ser 982 | deletion |
| - | Leu 983 | deletion |
| - | Ser 984 | deletion |
| - | Asp 985 | deletion |
| - | Val 986 | deletion |
| - | Glu 987 | deletion |
| - | Glu 988 | deletion |
| - | Glu 989 | deletion |
| - | Glu 990 | deletion |
| - | Ala 991 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36557.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1019.9 | |
| All* | Total formula weight | 37576.9 |
