3C2I

The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Methyl-CpG-binding protein 2	polymer	97	11281.4	1	UniProt (P51608) Pfam (PF01429) In PDB	Homo sapiens (human)	MeCP-2 protein, MeCP2
2	B	DNA (5'-D(*DTP*DCP*DTP*DGP*DGP*DAP*DAP*(5CM)P*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DTP*DTP*DCP*DTP*DA)-3')	polymer	20	6138.0	1
3	C	DNA (5'-D(*DAP*DTP*DAP*DGP*DAP*DAP*DGP*DAP*DAP*DTP*DTP*DCP*(5CM)P*DGP*DTP*DTP*DCP*DCP*DAP*DG)-3')	polymer	20	6156.0	1
4		water	water		18.0	47	Chemie (HOH)

Sequence modifications

A: 77 - 167 (UniProt: P51608)

PDB	External Database	Details
Mse 140	Ala 140	engineered mutation
His 168	-	expression tag
His 169	-	expression tag
His 170	-	expression tag
His 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	23575.4
All*	Total formula weight	23575.4

*Water molecules are not included.