3C1X
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 373 | 41849.3 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | MET PROTO-ONCOGENE TYROSINE KINASE, C-MET, HGF RECEPTOR, HGF/SF RECEPTOR, SF receptor, Scatter factor receptor |
| 2 | B (A) | N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide | non-polymer | 535.5 | 1 | Chemie (CKK) | |||
| 3 | C (A) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 988 | - | expression tag |
| Ser 989 | - | expression tag |
| Pro 990 | - | expression tag |
| Ile 991 | - | expression tag |
| Asp 992 | - | expression tag |
| Pro 993 | - | expression tag |
| Met 994 | - | expression tag |
| Gly 995 | - | expression tag |
| His 996 | - | expression tag |
| His 997 | - | expression tag |
| His 998 | - | expression tag |
| His 999 | - | expression tag |
| His 1000 | - | expression tag |
| His 1001 | - | expression tag |
| Gly 1002 | - | expression tag |
| Arg 1003 | - | expression tag |
| Arg 1004 | - | expression tag |
| Arg 1005 | - | expression tag |
| Ala 1006 | - | expression tag |
| Ser 1007 | - | expression tag |
| Val 1008 | - | expression tag |
| Ala 1009 | - | expression tag |
| Ala 1010 | - | expression tag |
| Gly 1011 | - | expression tag |
| Ile 1012 | - | expression tag |
| Leu 1013 | - | expression tag |
| Val 1014 | - | expression tag |
| Pro 1015 | - | expression tag |
| Arg 1016 | - | expression tag |
| Gly 1017 | - | expression tag |
| Ser 1018 | - | expression tag |
| Pro 1019 | - | expression tag |
| Gly 1020 | - | expression tag |
| Leu 1021 | - | expression tag |
| Asp 1022 | - | expression tag |
| Gly 1023 | - | expression tag |
| Ile 1024 | - | expression tag |
| Cys 1025 | - | expression tag |
| Ser 1026 | - | expression tag |
| Ile 1027 | - | expression tag |
| Glu 1028 | - | expression tag |
| Glu 1029 | - | expression tag |
| Leu 1030 | - | expression tag |
| Ser 1031 | - | expression tag |
| Thr 1032 | - | expression tag |
| Ser 1033 | - | expression tag |
| Leu 1034 | - | expression tag |
| Tyr 1035 | - | expression tag |
| Lys 1036 | - | expression tag |
| Lys 1037 | - | expression tag |
| Ala 1038 | - | expression tag |
| Gly 1039 | - | expression tag |
| Ser 1040 | - | expression tag |
| Glu 1041 | - | expression tag |
| Asn 1042 | - | expression tag |
| Leu 1043 | - | expression tag |
| Tyr 1044 | - | expression tag |
| Phe 1045 | - | expression tag |
| Gln 1046 | - | expression tag |
| Gly 1047 | - | expression tag |
| Ala 1048 | - | expression tag |
| Phe 1194 | Tyr 1194 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
| Leu 1272 | Val 1272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41849.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 535.5 | |
| All* | Total formula weight | 42384.8 |
