3C16
Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Adenylate cyclase type 5 | polymer | 225 | 25526.5 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (Dog) | Adenylate cyclase type V, ATP pyrophosphate-lyase 5, Adenylyl cyclase 5, Ca2+, -inhibitable adenylyl cyclase |
| 2 | B (B) | Adenylate cyclase type 2 | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (rat) | Adenylate cyclase type II, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2 |
| 3 | C (C) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 402 | 46712.5 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (bovine) | Adenylate cyclase-stimulating G alpha protein |
| 4 | D, E (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 5 | F (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) PubChem (16757823) PubChem (3413) PubChem (176519959) PubChem (47936) PubChem (44120009) PubChem (44363887) PubChem (46783813) PubChem (69645774) PubChem (73759682) PubChem (6603852) PubChem (6604815) PubChem (6610344) PubChem (337799) PubChem (90751269) PubChem (9844450) PubChem (91213948) PubChem (486148) PubChem (92209816) PubChem (92209817) PubChem (95566308) PubChem (95566309) PubChem (13361560) PubChem (13361561) PubChem (13361564) PubChem (13361565) PubChem (92209815) PubChem (5702265) PubChem (124404343) PubChem (117777632) PubChem (133612037) PubChem (124303810) PubChem (124352399) PubChem (124815399) PubChem (124815400) PubChem (129009935) PubChem (129010250) PubChem (139024465) PubChem (142159939) PubChem (146225314) PubChem (159992414) PubChem (162705519) PubChem (162884402) PubChem (163835172) PubChem (168749335) PubChem (171322913) | |||
| 6 | G (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 7 | H (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 8 | I (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 9 | J (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) PubChem (135398675) PubChem (135476260) PubChem (136073095) PubChem (136440011) PubChem (137176535) PubChem (169450542) | |||
| 10 | K (A) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 363 - 580 (UniProt: P30803)
C: -2 - 372 (UniProt: P04896)
| PDB | External Database | Details |
|---|---|---|
| Met 356 | - | expression tag |
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
| His 361 | - | expression tag |
| His 362 | - | expression tag |
| Met 476 | Val 557 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 373 | - | expression tag |
| Gly 374 | - | expression tag |
| His 375 | - | expression tag |
| His 376 | - | expression tag |
| His 377 | - | expression tag |
| His 378 | - | expression tag |
| His 379 | - | expression tag |
| His 380 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95956.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1596.8 | |
| All* | Total formula weight | 97552.9 |
