3C14
Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Adenylate cyclase type 5 | polymer | 225 | 25526.5 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (Dog) | Adenylate cyclase type V, ATP pyrophosphate-lyase 5, Adenylyl cyclase 5, Ca2+, -inhibitable adenylyl cyclase |
| 2 | B (B) | Adenylate cyclase type 2 | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (rat) | Adenylate cyclase type II, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2 |
| 3 | C (C) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 402 | 46712.5 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (bovine) | Adenylate cyclase-stimulating G alpha protein |
| 4 | D (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) PubChem (16757823) PubChem (3413) PubChem (176519959) PubChem (47936) PubChem (44120009) PubChem (44363887) PubChem (46783813) PubChem (69645774) PubChem (73759682) PubChem (6603852) PubChem (6604815) PubChem (6610344) PubChem (337799) PubChem (90751269) PubChem (9844450) PubChem (91213948) PubChem (486148) PubChem (92209816) PubChem (92209817) PubChem (95566308) PubChem (95566309) PubChem (13361560) PubChem (13361561) PubChem (13361564) PubChem (13361565) PubChem (92209815) PubChem (5702265) PubChem (124404343) PubChem (117777632) PubChem (133612037) PubChem (124303810) PubChem (124352399) PubChem (124815399) PubChem (124815400) PubChem (129009935) PubChem (129010250) PubChem (139024465) PubChem (142159939) PubChem (146225314) PubChem (159992414) PubChem (162705519) PubChem (162884402) PubChem (163835172) PubChem (168749335) PubChem (171322913) | |||
| 5 | E (A) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) PubChem (4995) | |||
| 6 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 7 | G (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 8 | H (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 9 | I (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) PubChem (135398675) PubChem (135476260) PubChem (136073095) PubChem (136440011) PubChem (137176535) PubChem (169450542) | |||
| 10 | J, K, L (A, B, C) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 363 - 580 (UniProt: P30803)
C: 1 - 394 (UniProt: P04896)
| PDB | External Database | Details |
|---|---|---|
| Met 356 | - | expression tag |
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
| His 361 | - | expression tag |
| His 362 | - | expression tag |
| Met 476 | Val 557 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 395 | - | expression tag |
| Gly 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95956.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1225.5 | |
| All* | Total formula weight | 97181.6 |
