3C14
Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Adenylate cyclase type 5 | polymer | 225 | 25526.5 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (Dog) | Adenylate cyclase type V, ATP pyrophosphate-lyase 5, Adenylyl cyclase 5, Ca2+, -inhibitable adenylyl cyclase |
| 2 | B (B) | Adenylate cyclase type 2 | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (rat) | Adenylate cyclase type II, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2 |
| 3 | C (C) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 402 | 46712.5 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (bovine) | Adenylate cyclase-stimulating G alpha protein |
| 4 | D (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) | |||
| 5 | E (A) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) | |||
| 6 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | G (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 8 | H (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | I (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 10 | J, K, L (A, B, C) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 363 - 580 (UniProt: P30803)
C: 1 - 394 (UniProt: P04896)
| PDB | External Database | Details |
|---|---|---|
| Met 356 | - | expression tag |
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
| His 361 | - | expression tag |
| His 362 | - | expression tag |
| Met 476 | Val 557 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 395 | - | expression tag |
| Gly 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95956.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1225.5 | |
| All* | Total formula weight | 97181.6 |
