3BUG
BACE-1 complexed with compound 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BETA-SECRETASE 1 | polymer | 409 | 45554.0 | 1 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (human) | BETA-SITE APP CLEAVING ENZYME 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2 |
| 2 | B (A) | 4-(2-aminoethyl)-2-ethylphenol | non-polymer | 165.2 | 1 | Chemie (AEH) | |||
| 3 | C (A) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A: -15 - 393 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Ala 246 | Lys 307 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45554.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 165.2 | |
| All* | Total formula weight | 45719.2 |
