3BRT

NEMO/IKK association domain structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha	polymer	47	5293.9	2	UniProt (O14920) UniProt (O15111) Pfam (PF12179)	Homo sapiens (human)	I-kappa-B-kinase beta, IkBKB, IKK-beta, IKK-B, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB,I kappa-B kinase alpha, IkBKA, IKK-alpha, IKK-A, IkappaB kinase, I-kappa-B kinase 1, IKK1, Conserved helix-loop-helix, ubiquitous kinase, Nuclear factor NF-kappa-B, inhibitor kinase alpha, NFKBIKA,
2	B, D (B, D)	NF-kappa-B essential modulator	polymer	68	8274.4	2	UniProt (Q9Y6K9) Pfam (PF11577)	Homo sapiens (human)	NEMO, NF-kappa-B essential modifier, Inhibitor of nuclear factor kappa-B kinase subunit gamma, IkB kinase subunit gamma, I-kappa-B kinase gamma, IKK-gamma, IKKG, IkB kinase-associated protein 1, IKKAP1, FIP-3
3	E, F, G, H (A, B, C, D)	water	water		18.0	62	Chemie (HOH)

Sequence modifications

A, C: 701 - 730 (UniProt: O14920)

PDB	External Database	Details
Ala 698	-	expression tag
Met 699	-	expression tag
Ala 700	-	expression tag

A, C: 731 - 744 (UniProt: O15111)
B, D: 44 - 111 (UniProt: Q9Y6K9)

PDB	External Database	Details
Trp 45	Gln 45	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	27136.7
All*	Total formula weight	27136.7

*Water molecules are not included.