3BQN
LFA-1 I domain bound to inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, C) | Integrin alpha-L | polymer | 182 | 20820.9 | 2 | UniProt (P20701) Pfam (PF00092) | Homo sapiens (Human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a antigen |
| 2 | C, D (B, C) | 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfanyl}-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl}morpholine | non-polymer | 568.5 | 2 | Chemie (BQN) | |||
| 3 | E, F (B, C) | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
B, C: 128 - 309 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Trp 189 | Arg 214 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41641.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1137.1 | |
| All* | Total formula weight | 42778.8 |
