3BPR
Crystal structure of catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor C52
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Proto-oncogene tyrosine-protein kinase MER | polymer | 313 | 35889.4 | 4 | UniProt (Q12866) Pfam (PF07714) In PDB | Homo sapiens (human) | C-mer, Receptor tyrosine kinase MerTK |
2 | A, B, C, D | 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE | non-polymer | 346.8 | 4 | Chemie (OLP) | |||
3 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
4 | C, D | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 570 - 864 (UniProt: Q12866)
PDB | External Database | Details |
---|---|---|
Met 552 | - | expression tag |
Gly 553 | - | expression tag |
Ser 554 | - | expression tag |
Ser 555 | - | expression tag |
His 556 | - | expression tag |
His 557 | - | expression tag |
His 558 | - | expression tag |
His 559 | - | expression tag |
His 560 | - | expression tag |
His 561 | - | expression tag |
Ser 562 | - | expression tag |
Ser 563 | - | expression tag |
Gly 564 | - | expression tag |
Leu 565 | - | expression tag |
Val 566 | - | expression tag |
Pro 567 | - | expression tag |
Arg 568 | - | expression tag |
Gly 569 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 143557.7 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1481.2 | |
All* | Total formula weight | 145038.9 |