3BPL
Crystal structure of the IL4-IL4R-Common Gamma ternary complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Interleukin-4 | polymer | 129 | 14989.2 | 1 | UniProt (P05112) Pfam (PF00727) In PDB | Homo sapiens (human) | IL-4, B-cell stimulatory factor 1, BSF-1, Lymphocyte stimulatory factor 1, Binetrakin, Pitrakinra |
2 | B | Interleukin-4 receptor alpha chain | polymer | 205 | 23470.3 | 1 | UniProt (P24394) Pfam (PF09238) In PDB | Homo sapiens (human) | IL-4R-alpha, CD124 antigen, Soluble interleukin-4 receptor alpha chain |
3 | C | Cytokine receptor common gamma chain | polymer | 199 | 23912.7 | 1 | UniProt (P31785) Pfam (PF22012) Pfam (PF21605) In PDB | Homo sapiens (human) | Gamma-C, Interleukin-2 receptor gamma chain, IL-2R gamma chain, p64, CD132 antigen |
4 | D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
6 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
7 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
B: 2 - 202 (UniProt: P24394)
C: 34 - 232 (UniProt: P31785)
PDB | External Database | Details |
---|---|---|
Ala -2 | - | expression tag |
Asp -1 | - | expression tag |
Pro 0 | - | expression tag |
Phe 1 | - | expression tag |
Gln 28 | Asn 53 | engineered mutation |
Gln 73 | Asn 98 | engineered mutation |
Gln 109 | Asn 134 | engineered mutation |
Gln 151 | Asn 176 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gln 53 | Asn 75 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 62372.3 | |
Branched | Number of molecules | 2 |
Total formula weight | 994.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 64030.8 |