3BOW
Structure of M-calpain in complex with Calpastatin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Calpain-2 catalytic subunit | polymer | 714 | 81577.8 | 1 | UniProt (Q07009) Pfam (PF00648) Pfam (PF01067) Pfam (PF13833) In PDB | Rattus norvegicus (brown rat rat rats) | Calpain-2 large subunit, Calcium-activated neutral proteinase 2, CANP 2, Calpain M-type, M-calpain, Millimolar-calpain |
2 | B | Calpain small subunit 1 | polymer | 184 | 21305.0 | 1 | UniProt (Q64537) Pfam (PF13833) In PDB | Rattus norvegicus (brown rat rat rats) | CSS1, Calcium-dependent protease small subunit 1, Calcium-dependent protease small subunit, CDPS, Calpain regulatory subunit, Calcium-activated neutral proteinase small subunit, CANP small subunit |
3 | C | Calpastatin | polymer | 95 | 10765.7 | 1 | UniProt (P27321) Pfam (PF00748) In PDB | Rattus norvegicus (brown rat rat rats) | Calpain inhibitor |
4 | A, B | CALCIUM ION | non-polymer | 40.1 | 10 | Chemie (CA) | |||
5 | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
A: 1 - 700 (UniProt: Q07009)
B: 88 - 270 (UniProt: Q64537)
C: 571 - 664 (UniProt: P27321)
PDB | External Database | Details |
---|---|---|
Ser 105 | Cys 105 | engineered mutation |
Gly 701 | - | expression tag |
Lys 702 | - | expression tag |
Leu 703 | - | expression tag |
Ala 704 | - | expression tag |
Ala 705 | - | expression tag |
Ala 706 | - | expression tag |
Leu 707 | - | expression tag |
Glu 708 | - | expression tag |
His 709 | - | expression tag |
His 710 | - | expression tag |
His 711 | - | expression tag |
His 712 | - | expression tag |
His 713 | - | expression tag |
His 714 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 87 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 570 | - | expression tag |
Pro 646 | Leu 646 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 113648.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 400.8 | |
All* | Total formula weight | 114049.3 |