3BMY
Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heat shock protein HSP 90-alpha | polymer | 226 | 25412.6 | 1 | UniProt (P07900) Pfam (PF13589) | Homo sapiens (Human) | HSP 86, Renal carcinoma antigen NY-REN-38 |
| 2 | B (A) | 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol | non-polymer | 389.8 | 1 | Chemie (CXZ) | |||
| 3 | C (A) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 11 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| - | Glu 16 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25412.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 389.8 | |
| All* | Total formula weight | 25802.4 |
