3BGX
E. coli Thymidylate Synthase C146S mutant complexed with dTMP and MTF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Thymidylate synthase | polymer | 264 | 30543.6 | 1 | UniProt (P0A884) Pfam (PF00303) In PDB | Escherichia coli | TS, TSase |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | A | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) | |||
| 4 | A | N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid | non-polymer | 457.4 | 1 | Chemie (MEF) | |||
| 5 | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A: 1 - 264 (UniProt: P0A884)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | Cys 146 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30543.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 971.8 | |
| All* | Total formula weight | 31515.4 |
