3BG9

Crystal Structure of Human Pyruvate Carboxylase (missing the biotin carboxylase domain at the N-terminus) F1077A Mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Pyruvate carboxylase, mitochondrial	polymer	718	78720.2	4	UniProt (P11498) Pfam (PF00682) Pfam (PF02436) Pfam (PF00364) In PDB	Homo sapiens (human)	Pyruvic carboxylase, PCB
2	A, B, C, D	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)

Sequence modifications

A, B, C, D: 482 - 1178 (UniProt: P11498)

PDB	External Database	Details
Met 461	-	expression tag
Gly 462	-	expression tag
Ser 463	-	expression tag
Ser 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag
His 469	-	expression tag
His 470	-	expression tag
Ser 471	-	expression tag
Ser 472	-	expression tag
Gly 473	-	expression tag
Leu 474	-	expression tag
Val 475	-	expression tag
Pro 476	-	expression tag
Arg 477	-	expression tag
Gly 478	-	expression tag
Ser 479	-	expression tag
His 480	-	expression tag
Met 481	-	expression tag
Ala 1077	Phe 1077	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	314880.9
Non-Polymers*	Number of molecules	4
	Total formula weight	219.8
All*	Total formula weight	315100.6

*Water molecules are not included.