3BG3

Crystal Structure of Human Pyruvate Carboxylase (missing the biotin carboxylase domain at the N-terminus)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate carboxylase, mitochondrial	polymer	718	78839.3	4	UniProt (P11498) Pfam (PF00682) Pfam (PF02436) Pfam (PF00364)	Homo sapiens (human)	Pyruvic carboxylase, PCB
2	E, H, J, L (A, B, C, D)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN) PubChem (27854)
3	F, I, K, M (A, B, C, D)	PYRUVIC ACID	non-polymer		88.1	4	Chemie (PYR) PubChem (1060)
4	G (A)	5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL	non-polymer		228.3	1	Chemie (BTI) PubChem (17965293) PubChem (58695178) PubChem (87862616) PubChem (89380030) PubChem (118178845) PubChem (121245621) PubChem (11840927) PubChem (144280373) PubChem (146214575) PubChem (146243400) PubChem (155384529) PubChem (156457378)

Sequence modifications

A, B, C, D: 482 - 1178 (UniProt: P11498)

PDB	External Database	Details
Met 461	-	expression tag
Gly 462	-	expression tag
Ser 463	-	expression tag
Ser 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag
His 469	-	expression tag
His 470	-	expression tag
Ser 471	-	expression tag
Ser 472	-	expression tag
Gly 473	-	expression tag
Leu 474	-	expression tag
Val 475	-	expression tag
Pro 476	-	expression tag
Arg 477	-	expression tag
Gly 478	-	expression tag
Ser 479	-	expression tag
His 480	-	expression tag
Met 481	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	315357.2
Non-Polymers*	Number of molecules	9
	Total formula weight	800.3
All*	Total formula weight	316157.6

*Water molecules are not included.