3BG3

Crystal Structure of Human Pyruvate Carboxylase (missing the biotin carboxylase domain at the N-terminus)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate carboxylase, mitochondrial	polymer	718	78839.3	4	UniProt (P11498) Pfam (PF00682) Pfam (PF02436) Pfam (PF00364)	Homo sapiens (human)	Pyruvic carboxylase, PCB
2	E, H, J, L (A, B, C, D)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3	F, I, K, M (A, B, C, D)	PYRUVIC ACID	non-polymer		88.1	4	Chemie (PYR)
4	G (A)	5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL	non-polymer		228.3	1	Chemie (BTI)

Sequence modifications

A, B, C, D: 482 - 1178 (UniProt: P11498)

PDB	External Database	Details
Met 461	-	expression tag
Gly 462	-	expression tag
Ser 463	-	expression tag
Ser 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag
His 469	-	expression tag
His 470	-	expression tag
Ser 471	-	expression tag
Ser 472	-	expression tag
Gly 473	-	expression tag
Leu 474	-	expression tag
Val 475	-	expression tag
Pro 476	-	expression tag
Arg 477	-	expression tag
Gly 478	-	expression tag
Ser 479	-	expression tag
His 480	-	expression tag
Met 481	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	315357.2
Non-Polymers*	Number of molecules	9
	Total formula weight	800.3
All*	Total formula weight	316157.6

*Water molecules are not included.