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3BBT

crystal structure of the ErbB4 kinase in complex with lapatinib

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(B, D)
Receptor tyrosine-protein kinase erbB-4polymer32837491.52UniProt (Q15303)
Pfam (PF07714)
Homo sapiens (human)p180erbB4, Tyrosine kinase-type cell surface receptor HER4
2C, D
(B, D)
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINEnon-polymer581.12Chemie (FMM)
3E, F
(B, D)
waterwater18.084Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight74982.9
Non-Polymers*Number of molecules2
Total formula weight1162.1
All*Total formula weight76145.0
*Water molecules are not included.

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PDB entries from 2025-10-15

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