3BB2

Crystal structure of L26D/D28N mutant of Human acidic fibroblast growth factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heparin-binding growth factor 1	polymer	146	16687.7	2	UniProt (P05230) Pfam (PF00167) In PDB	Homo sapiens (human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A, B	FORMIC ACID	non-polymer		46.0	3	Chemie (FMT)
4		water	water		18.0	222	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Asp 26	Leu 41	engineered mutation
Asn 28	Asp 43	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33375.4
Non-Polymers*	Number of molecules	4
	Total formula weight	234.1
All*	Total formula weight	33609.5

*Water molecules are not included.