3BAD

Crystal structure of D70A/H93G mutant of Human acidic fibroblast growth factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heparin-binding growth factor 1	polymer	146	16561.6	2	UniProt (P05230) Pfam (PF00167) In PDB	Homo sapiens (human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3		water	water		18.0	75	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ala 70	Asp 85	engineered mutation
Gly 93	His 108	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33123.3
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	33315.4

*Water molecules are not included.