3BA5

Crystal structure of D28A mutant of Human acidic fibroblast growth factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Heparin-binding growth factor 1	polymer	146	16642.7	2	UniProt (P05230) Pfam (PF00167)	Homo sapiens (human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	C (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	D, E, F, G, H (A, B)	FORMIC ACID	non-polymer		46.0	5	Chemie (FMT)
4	I, J (A, B)	water	water		18.0	159	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Ala 28	Asp 43	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33285.5
Non-Polymers*	Number of molecules	6
	Total formula weight	326.2
All*	Total formula weight	33611.7

*Water molecules are not included.