3B76

Crystal structure of the third PDZ domain of human ligand-of-numb protein-X (LNX1) in complex with the C-terminal peptide from the coxsackievirus and adenovirus receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	E3 ubiquitin-protein ligase LNX	polymer	118	12824.5	2	UniProt (Q8TBB1) Pfam (PF00595)	Homo sapiens (human)	Numb-binding protein 1, Ligand of Numb-protein X 1
2	C (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
3	D, E (B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	F, G (A, B)	water	water		18.0	124	Chemie (HOH)

Sequence modifications

A, B: 408 - 498 (UniProt: Q8TBB1)

PDB	External Database	Details
Met 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
Ser 392	-	expression tag
Ser 393	-	expression tag
Gly 394	-	expression tag
Val 395	-	expression tag
Asp 396	-	expression tag
Leu 397	-	expression tag
Gly 398	-	expression tag
Thr 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag
Ser 406	-	expression tag
Met 407	-	expression tag
Gly 499	-	SEE REMARK 999
Ser 500	-	SEE REMARK 999
Ile 501	-	SEE REMARK 999
Val 502	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	25649.0
Non-Polymers*	Number of molecules	3
	Total formula weight	147.1
All*	Total formula weight	25796.1

*Water molecules are not included.