3B1M
Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator Cerco-A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor gamma | polymer | 283 | 32412.6 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | B (B) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 19 | 2067.4 | 1 | UniProt (Q9UBK2) | Homo sapiens | PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, Ligand effect modulator 6 |
| 3 | C (A) | (9aS)-8-acetyl-N-[(2-ethylnaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide | non-polymer | 513.5 | 1 | Chemie (KRC) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A: 206 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met 195 | - | expression tag |
| Arg 196 | - | expression tag |
| Gly 197 | - | expression tag |
| Ser 198 | - | expression tag |
| His 199 | - | expression tag |
| His 200 | - | expression tag |
| His 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| His 204 | - | expression tag |
| Gly 205 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34480.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 513.5 | |
| All* | Total formula weight | 34993.5 |
