3AOX
X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 344 | 38814.6 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | B (A) | 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | non-polymer | 482.6 | 1 | Chemie (EMH) | |||
| 3 | C, D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | G (A) | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A: 1069 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1068 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38814.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 730.9 | |
| All* | Total formula weight | 39545.5 |
