3AH3

Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Homoisocitrate dehydrogenase	polymer	334	35862.3	4	UniProt (Q72IW9) Pfam (PF00180) In PDB	Thermus thermophilus	LR5-1
2	A, B, C, D	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
4		water	water		18.0	311	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 334 (UniProt: Q72IW9)

PDB	External Database	Details
Tyr 15	His 15	SEE REMARK 999
Val 57	Glu 57	SEE REMARK 999
Ile 72	Ser 72	SEE REMARK 999
Met 85	Arg 85	SEE REMARK 999
Ala 86	Tyr 86	SEE REMARK 999
Thr 208	Met 208	SEE REMARK 999
Tyr 217	Phe 217	SEE REMARK 999
Met 238	Val 238	SEE REMARK 999
Met 310	Arg 310	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	143449.3
Non-Polymers*	Number of molecules	15
	Total formula weight	1067.0
All*	Total formula weight	144516.3

*Water molecules are not included.