3AC4

Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
AProto-oncogene tyrosine-protein kinase LCKpolymer28533065.61
UniProt (P06239)
Pfam (PF07714)
Homo sapiens (human)@PDBjLYMPHOCYTE KINASE, LCK, Lymphocyte cell-specific protein-tyrosine kinase, p56-LCK, LSK, T cell-specific protein-tyrosine kinase
SULFATE IONnon-polymer96.12
DIMETHYL SULFOXIDEnon-polymer78.11
5-[(2-amino-1,1-dimethylethyl)amino]-7-[(3,5-dimethoxyphenyl)amino][1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamidenon-polymer400.41
waterwater18.094

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains1
Total molecular weight33065.6
Non-Polymers*Number of molecules4
Total molecular weight670.7
All*Total molecular weight33736.3
*Water molecules are not included.