37UT
Cryo-EM structure of human Fibroblast Activation Protein alpha in complex with huB12 IgG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (B, A) | Prolyl endopeptidase FAP | polymer | 753 | 87021.7 | 2 | UniProt (Q12884) | Homo sapiens (human) | 170 kDa melanoma membrane-bound gelatinase,Dipeptidyl peptidase FAP,Fibroblast activation protein alpha,FAPalpha,Gelatine degradation protease FAP,Integral membrane serine protease,Post-proline cleaving enzyme,Serine integral membrane protease,SIMP,Surface-expressed protease,Seprase |
| 2 | B, E (F, E) | huB12 IgG light chain | polymer | 213 | 23215.7 | 2 | Homo sapiens (human) | ||
| 3 | C, F (D, C) | huB12 IgG heavy chain | polymer | 444 | 48543.5 | 2 | Homo sapiens (human) | ||
| 4 | G, H, I, J, K... (G, H, I, J, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB | |||
| 5 | O, P, Q, R (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) PubChem (24139) |
Sequence modifications
B, A: 39 - 756 (UniProt: Q12884)
| PDB | External Database | Details |
|---|---|---|
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Gly 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Gly 23 | - | expression tag |
| Gly 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Leu 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Pro 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Val 31 | - | expression tag |
| His 32 | - | expression tag |
| Asn 33 | - | expression tag |
| Ser 34 | - | expression tag |
| Glu 35 | - | expression tag |
| Glu 36 | - | expression tag |
| Asn 37 | - | expression tag |
| Thr 38 | - | expression tag |
| Ser 757 | - | expression tag |
| Leu 758 | - | expression tag |
| Ser 759 | - | expression tag |
| Asp 760 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 317561.8 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 3395.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 321841.8 |
