37RI
Multi-parameter optimization of a novel anti-TROP2 MMAE Antibody-Drug-Conjugate for solid tumor therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | MK6837 Heavy Chain | polymer | 241 | 26038.2 | 2 | Homo sapiens | ||
| 2 | B, D (B, D) | MK6837 Light Chain | polymer | 234 | 25540.6 | 2 | Homo sapiens | ||
| 3 | E, F (E, F) | Tumor-associated calcium signal transducer 2 | polymer | 284 | 32444.1 | 2 | UniProt (P09758) | Homo sapiens (human) | Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,Pancreatic carcinoma marker protein GA733-1 |
| 4 | G, H, I, J (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | K, L (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) PubChem (24139) | |||
| 6 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
E, F: 31 - 274 (UniProt: P09758)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Met -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Val -3 | - | expression tag |
| Asn -2 | - | expression tag |
| Val -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Val 2 | - | expression tag |
| Phe 3 | - | expression tag |
| Met 4 | - | expression tag |
| Val 5 | - | expression tag |
| Val 6 | - | expression tag |
| Tyr 7 | - | expression tag |
| Ile 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Ile 11 | - | expression tag |
| Tyr 12 | - | expression tag |
| Ala 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| Glu 24 | - | expression tag |
| Asn 25 | - | expression tag |
| Leu 26 | - | expression tag |
| Tyr 27 | - | expression tag |
| Phe 28 | - | expression tag |
| Gln 29 | - | expression tag |
| Gly 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 168045.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 690.7 | |
| All* | Total formula weight | 168736.6 |
