37BG
Crystal Structure of Histone-lysine N-methyltransferase from Leishmania major in complex with S-ADENOSYLMETHIONINE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 258 | 29630.0 | 4 | UniProt (Q4QIU2) | Leishmania major strain Friedlin | Histone H3-K76 methyltransferase,Histone H3-K79 methyltransferase,Histone-lysine N-methyltransferase,H3 lysine-76 specific |
| 2 | E, H, K, O (A, B, C, D) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
| 3 | F, I, L, P (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) PubChem (32051) | |||
| 4 | G, J, M, Q (A, B, C, D) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 4 | Chemie (BTB) PubChem (81462) | |||
| 5 | N (C) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) PubChem (8200) | |||
| 6 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 604 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 50 - 299 (UniProt: Q4QIU2)
| PDB | External Database | Details |
|---|---|---|
| Met 42 | - | initiating methionine |
| Ala 43 | - | expression tag |
| His 44 | - | expression tag |
| His 45 | - | expression tag |
| His 46 | - | expression tag |
| His 47 | - | expression tag |
| His 48 | - | expression tag |
| His 49 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 118520.1 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2886.6 | |
| All* | Total formula weight | 121406.7 |
