36IV
Cryo-EM structure of BRD4 BD1 bound to acetylated nucleosomes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3 | polymer | 135 | 15345.0 | 2 | UniProt (A0A310TTQ1) | Xenopus laevis (African clawed frog) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 103 | 11402.3 | 2 | UniProt (P62799) | Xenopus laevis (African clawed frog) | |
| 3 | C, G (C, G) | Histone H2A type 1-B/E | polymer | 129 | 14034.4 | 2 | UniProt (P04908) | Homo sapiens (human) | Histone H2A.2,Histone H2A/a,Histone H2A/m |
| 4 | D, H (D, H) | Histone H2B type 1-J | polymer | 125 | 13804.0 | 2 | UniProt (P06899) | Homo sapiens (human) | Histone H2B.1,Histone H2B.r,H2B/r |
| 5 | I (I) | DNA (132-MER) | polymer | 165 | 50683.3 | 1 | synthetic construct | ||
| 6 | J (J) | DNA (130-MER) | polymer | 165 | 51190.6 | 1 | synthetic construct | ||
| 7 | K (K) | Isoform C of Bromodomain-containing protein 4 | polymer | 722 | 80506.2 | 1 | UniProt (O60885) | Homo sapiens (human) | Protein HUNK1 |
Sequence modifications
B, F: 1 - 102 (UniProt: P62799)
K: 2 - 722 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 291551.5 | |
| All* | Total formula weight | 291551.5 |
