36CK
Crystal structure of human Argonaute2 in complex with a fully modified siRNA with a 5' methyl phosphate
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein argonaute-2 | polymer | 859 | 97402.2 | 1 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) | Homo sapiens (human) | hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
| 2 | B (B) | fully modified siRNA with a 5' methyl phosphate | polymer | 21 | 7056.6 | 1 | synthetic construct | ||
| 3 | C, D (A, B) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
| PDB | External Database | Details |
|---|---|---|
| Asp 387 | Ser 387 | engineered mutation |
| Ala 824 | Ser 824 | engineered mutation |
| Asp 828 | Ser 828 | engineered mutation |
| Asp 831 | Ser 831 | engineered mutation |
| Ala 834 | Ser 834 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 104458.8 | |
| All* | Total formula weight | 104458.8 |
