35WJ
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with an inhibitor UNC7467
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inositol polyphosphate multikinase | polymer | 261 | 29827.9 | 1 | UniProt (Q8NFU5) Pfam (PF03770) | Homo sapiens (human) | Inositol 1,3,4,6-tetrakisphosphate 5-kinase |
| 2 | B (A) | 3-([1,1'-biphenyl]-4-yl)-2,1-benzoxazole-5-carboxylic acid | non-polymer | 315.3 | 1 | Chemie (A1DH7) | |||
| 3 | C (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 4 | D (A) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 50 - 372 (UniProt: Q8NFU5)
| PDB | External Database | Details |
|---|---|---|
| Gly 46 | - | expression tag |
| Ser 47 | - | expression tag |
| Phe 48 | - | expression tag |
| Thr 49 | - | expression tag |
| Gly 373 | - | expression tag |
| Gly 374 | - | expression tag |
| Ser 375 | - | expression tag |
| Gly 376 | - | expression tag |
| Gly 377 | - | expression tag |
| Glu 378 | - | expression tag |
| Val 379 | - | expression tag |
| Glu 380 | - | expression tag |
| Val 381 | - | expression tag |
| Arg 382 | - | expression tag |
| Met 383 | - | expression tag |
| Ile 384 | - | expression tag |
| Asp 385 | - | expression tag |
| Phe 386 | - | expression tag |
| Ala 387 | - | expression tag |
| His 388 | - | expression tag |
| Val 389 | - | expression tag |
| Phe 390 | - | expression tag |
| Pro 391 | - | expression tag |
| Ser 392 | - | expression tag |
| Asn 393 | - | expression tag |
| Thr 394 | - | expression tag |
| Ile 395 | - | expression tag |
| Asp 396 | - | expression tag |
| Glu 397 | - | expression tag |
| Gly 398 | - | expression tag |
| Tyr 399 | - | expression tag |
| Val 400 | - | expression tag |
| Tyr 401 | - | expression tag |
| Gly 402 | - | expression tag |
| Leu 403 | - | expression tag |
| Lys 404 | - | expression tag |
| His 405 | - | expression tag |
| Leu 406 | - | expression tag |
| Ile 407 | - | expression tag |
| Ser 408 | - | expression tag |
| Val 409 | - | expression tag |
| Leu 410 | - | expression tag |
| Arg 411 | - | expression tag |
| Ser 412 | - | expression tag |
| Ile 413 | - | expression tag |
| Leu 414 | - | expression tag |
| Asp 415 | - | expression tag |
| Asn 416 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29827.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 393.5 | |
| All* | Total formula weight | 30221.4 |
