34CM
Crystal structure of human Cathepsin L in complex with 8-hydroxy-2,6-diazaspiro[3.5]nonan-5-one
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cathepsin L | polymer | 220 | 24177.7 | 4 | UniProt (P07711) | Homo sapiens (human) | |
| 2 | E (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) PubChem (8200) | |||
| 3 | F, J, K, S (A, B, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) PubChem (679) | |||
| 4 | G, L, M, O, P... (A, B, C, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) PubChem (8117) | |||
| 5 | H, N, W (A, B, D) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 6 | I (A) | (8~{R})-8-oxidanyl-2,6-diazaspiro[3.5]nonan-5-one | non-polymer | 156.2 | 1 | Chemie (A1KPM) | |||
| 7 | R (C) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) PubChem (62551) | |||
| 8 | T, U (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 9 | X (D) | (8~{S})-8-oxidanyl-2,6-diazaspiro[3.5]nonan-5-one | non-polymer | 156.2 | 1 | Chemie (A1KTO) | |||
| 10 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 601 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96710.7 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2374.9 | |
| All* | Total formula weight | 99085.6 |
