34CK
Crystal structure of human Cathepsin L in complex with 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cathepsin L | polymer | 220 | 24177.7 | 4 | UniProt (P07711) | Homo sapiens (human) | |
| 2 | E, I, S (A, B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 3 | F, G, J, K, N... (A, B, C, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 9 | Chemie (PEG) PubChem (8117) | |||
| 4 | H, L, U (A, B, D) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 5 | M (C) | (4~{S})-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinolin-4-ol | non-polymer | 209.2 | 1 | Chemie (A1KPN) | |||
| 6 | R (D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) PubChem (679) | |||
| 7 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 491 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96710.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1879.2 | |
| All* | Total formula weight | 98589.9 |
