32TO
T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor IID432
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA topoisomerase 2 | polymer | 779 | 89322.4 | 2 | UniProt (Q4DE53) Pfam (PF16898) Pfam (PF00521) | Trypanosoma cruzi | |
| 2 | C, F (C, J) | DNA (16-Mer) | polymer | 16 | 4824.1 | 2 | Escherichia coli | ||
| 3 | D, E (D, I) | DNA (12-Mer) | polymer | 12 | 3735.5 | 2 | Escherichia coli | ||
| 4 | G, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | H, J (A, B) | 2-(3-cyano-1,2,4-triazol-1-yl)-~{N}-[(3~{S})-1-(2-methylquinolin-6-yl)pyrrolidin-3-yl]ethanamide | non-polymer | 361.4 | 2 | Chemie (A1KFP) |
Sequence modifications
A, B: 401 - 1178 (UniProt: Q4DE53)
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 195764.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 771.4 | |
| All* | Total formula weight | 196535.5 |
