32QS
Ternary complex of TRIM21 and BRD4 in complex with PROTAC 1b
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase TRIM21 | polymer | 181 | 20551.1 | 1 | UniProt (P19474) Pfam (PF13765) Pfam (PF00622) | Homo sapiens (human) | 52 kDa Ro protein,52 kDa ribonucleoprotein autoantigen Ro/SS-A,RING finger protein 81,Ro(SS-A),Sjoegren syndrome type A antigen,SS-A,Tripartite motif-containing protein 21 |
| 2 | B (B) | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 3 | C (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 4 | D (A) | ~{N}-[(3-chloranylpyridin-4-yl)methyl]-~{N}-[6-[2-[(9~{S})-7-(4-chlorophenyl)-4,5-dimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]hexyl]-4-(4-fluoranyl-2-methylsulfanyl-phenyl)-2-methylsulfonyl-benzamide | non-polymer | 933.0 | 1 | Chemie (A1KEC) | |||
| 5 | E (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 287 - 465 (UniProt: P19474)
B: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 285 | - | expression tag |
| Met 286 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35650.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1039.1 | |
| All* | Total formula weight | 36689.6 |
