32JA
Structure of the pathogenic variant T186R of Human SHMT2 in the apo open dimeric conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 3 of Serine hydroxymethyltransferase, mitochondrial | polymer | 486 | 53865.2 | 1 | UniProt (P34897) | Homo sapiens (human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 2 | B (A) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 22 - 504 (UniProt: P34897)
| PDB | External Database | Details |
|---|---|---|
| Gly 19 | - | expression tag |
| Ser 20 | - | expression tag |
| His 21 | - | expression tag |
| Arg 186 | Thr 165 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53865.2 | |
| All* | Total formula weight | 53865.2 |
