32FD

Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go (alternative conformation)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	D(3) dopamine receptor,Dopamine 3 Receptor	polymer	573	62837.4	1	UniProt (P35462)	Homo sapiens (human)	Dopamine D3 receptor
2	B (A)	Engineered miniGo	polymer	226	25248.9	1		Homo sapiens
3	C (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	366	39728.4	1	UniProt (P62873)	Homo sapiens (human)	Transducin beta chain 1
4	D (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768)	Homo sapiens (human)	G gamma-I
5	E (S)	scFv16	polymer	256	27340.5	1		Mus musculus
6	F (R)	3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea	non-polymer		427.4	1	Chemie (7RU)

Sequence modifications

R: 1 - 400 (UniProt: P35462)
R: 401 - 573 (PDB: 32FD)
B: 0 - 339 (UniProt: P62873)

PDB	External Database	Details
Gly 340	-	expression tag
Ser 341	-	expression tag
Ser 342	-	expression tag
Gly 343	-	expression tag
Gly 344	-	expression tag
Gly 345	-	expression tag
Gly 346	-	expression tag
Ser 347	-	expression tag
Gly 348	-	expression tag
Gly 349	-	expression tag
Gly 350	-	expression tag
Gly 351	-	expression tag
Ser 352	-	expression tag
Ser 353	-	expression tag
Gly 354	-	expression tag
Val 355	-	expression tag
Ser 356	-	expression tag
Gly 357	-	expression tag
Trp 358	-	expression tag
Arg 359	-	expression tag
Leu 360	-	expression tag
Phe 361	-	expression tag
Lys 362	-	expression tag
Lys 363	-	expression tag
Ile 364	-	expression tag
Ser 365	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	163016.4
Non-Polymers*	Number of molecules	1
	Total formula weight	427.4
All*	Total formula weight	163443.8

*Water molecules are not included.