31VO

Crystal structure of amyloid beta 1-15 fragment bound to HLA-DR1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (B, D)	Amyloid-beta protein 40,HLA class II histocompatibility antigen DR beta chain	polymer	227	25656.3	2	UniProt (P05067) UniProt (D7RIG0)	Homo sapiens (human)	Abeta40,Beta-APP40,HLA-DRB1 protein,MHC class II antigen
2	B, D (A, C)	HLA class II histocompatibility antigen, DR alpha chain	polymer	198	22924.9	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	MHC class II antigen DRA
3	E, F, H (A, C)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)	Homo sapiens
4	G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG) PubChem (24139)	Homo sapiens
5	I, J, K, L (B, A, D, C)	water	water		18.0	182	Chemie (HOH)

Sequence modifications

B, D: -29 - -16 (UniProt: P05067)

PDB	External Database	Details
Gly -16	-	linker
Gly -16	-	linker
Gly -16	-	linker
Gly -16	-	linker
Gly -16	-	linker
Ser -16	-	linker
Gly -16	-	linker
Gly -16	-	linker
Gly -16	-	linker
Ser -16	-	linker
Gly -16	-	linker
Gly -16	-	linker
Ser -16	-	linker
Gly -16	-	linker
Gly -16	-	linker

B, D: -16 - 189 (UniProt: D7RIG0)

PDB	External Database	Details
Ser 190	-	expression tag
Leu 191	-	expression tag
Glu 192	-	expression tag
Val 193	-	expression tag
Leu 194	-	expression tag
Phe 195	-	expression tag
Gln 196	-	expression tag

A, C: 1 - 191 (UniProt: P01903)

PDB	External Database	Details
Ser 192	-	expression tag
Leu 193	-	expression tag
Glu 194	-	expression tag
Val 195	-	expression tag
Leu 196	-	expression tag
Phe 197	-	expression tag
Gln 198	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	97162.4
Non-Polymers*	Number of molecules	4
	Total formula weight	407.4
All*	Total formula weight	97569.8

*Water molecules are not included.