30AF
Complex between IgE-Fc and anti-IgE Fab aeFab98
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Isoform 1 of Immunoglobulin heavy constant epsilon | polymer | 327 | 36354.8 | 2 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (human) | Ig epsilon chain C region,Ig epsilon chain C region ND |
| 2 | C (H) | aeFab98 heavy chain | polymer | 216 | 22737.5 | 1 | Oryctolagus cuniculus | ||
| 3 | D (L) | aeFab98 light chain | polymer | 214 | 22817.3 | 1 | Oryctolagus cuniculus | ||
| 4 | E, F (C, D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 5 | G, H, I, L, M... (B, H, L) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) PubChem (753) | |||
| 6 | J, Q (B, H) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) PubChem (8117) | |||
| 7 | K (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 8 | R, S (H) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) PubChem (175) | |||
| 9 | V, W, X, Y (B, A, H, L) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
B, A: 224 - 547 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Asp 222 | - | expression tag |
| Ile 223 | - | expression tag |
| Ala 225 | Cys 105 | engineered mutation |
| Gln 265 | Asn 146 | engineered mutation |
| Gln 371 | Asn 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 118264.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1821.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1313.3 | |
| All* | Total formula weight | 121399.3 |
