2ZZC

Crystal structure of NADP(H):human thioredoxin reductase I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Thioredoxin reductase 1, cytoplasmic	polymer	513	56490.3	4	UniProt (Q16881) Pfam (PF07992) Pfam (PF02852)	Homo sapiens (Human)
2	E, G, I, K (A, B, C, D)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	4	Chemie (FAD)
3	F, H, J, L (A, B, C, D)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
4	M, N, O, P (A, B, C, D)	water	water		18.0	897	Chemie (HOH)

Sequence modifications

A, B, C, D: 0 - 499 (UniProt: Q16881)

PDB	External Database	Details
Met -13	-	expression tag
Ala -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Val -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Cys 498	U 648	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	225961.3
Non-Polymers*	Number of molecules	8
	Total formula weight	6115.8
All*	Total formula weight	232077.1

*Water molecules are not included.