2ZZ0

Crystal structure of human thioredoxin reductase I (SeCys 498 Cys)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Thioredoxin reductase 1, cytoplasmic	polymer	513	56490.3	4	UniProt (Q16881) Pfam (PF07992) Pfam (PF02852)	Homo sapiens (Human)	TR, Thioredoxin reductase TR1, KM-102-derived reductase-like factor, Gene associated with retinoid-IFN-induced mortality 12 protein, GRIM-12
2	E, G, I, K (A, B, C, D)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	4	Chemie (FAD)
3	F, H, J, L (A, B, C, D)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	M, N, O, P (A, B, C, D)	water	water		18.0	530	Chemie (HOH)

Sequence modifications

A, B, C, D: 0 - 499 (UniProt: Q16881)

PDB	External Database	Details
Met -13	-	expression tag
Ala -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Val -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Cys 498	Sec 648	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	225961.3
Non-Polymers*	Number of molecules	8
	Total formula weight	3526.5
All*	Total formula weight	229487.8

*Water molecules are not included.