2ZWE

Crystal structure of the copper-bound tyrosinase in complex with a caddie protein from streptomyces castaneoglobisporus obtained by soaking the deoxy-form crystal in dioxygen-saturated solution for 40 minutes

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosinase	polymer	281	32089.6	1	UniProt (Q83WS2) Pfam (PF00264)	Streptomyces castaneoglobisporus
2	B (B)	MelC	polymer	134	14219.8	1	UniProt (Q83WS1) Pfam (PF06236)	Streptomyces castaneoglobisporus	CADDIE PROTEIN ORF378
3	C, D, E, I (A, B)	COPPER (II) ION	non-polymer		63.5	4	Chemie (CU)
4	F, G, H, J (A, B)	NITRATE ION	non-polymer		62.0	4	Chemie (NO3)
5	K, L (A, B)	water	water		18.0	437	Chemie (HOH)

Sequence modifications

A: 1 - 273 (UniProt: Q83WS2)

PDB	External Database	Details
Ser 123	Phe 123	conflict
Leu 274	-	expression tag
Glu 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag

B: 1 - 126 (UniProt: Q83WS1)

PDB	External Database	Details
Arg 60	Gly 60	conflict
Ala 62	Gly 62	conflict
Leu 127	-	expression tag
Glu 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	46309.4
Non-Polymers*	Number of molecules	8
	Total formula weight	502.2
All*	Total formula weight	46811.6

*Water molecules are not included.